Wednesday's Movie Mashup No. 2

Thank you to people for guessing.  It even inspired a twitter feed so you can follow my blog @In_Entertain if you want to try to get notified as soon as this is up.  Last week's clue:

"An Irish couple come to America to seek their fortune, but she eventually gets Alzheimer's and can't remember his name"

Answer:  Far and Away from Her

Leader board:
David - 1

This week's clue:

"Two men have terrible adventures while they travel across the country so one man can enjoy an evening out with his wife that also goes awry"

If you think you know it, leave your guess in the comments section.